Invalid prompt error (while I'm working on code that runs a liquid handler)

Open 💬 2 comments Opened May 23, 2026 by teedr
💡 Likely answer: A maintainer (github-actions[bot], contributor) responded on this thread — see the highlighted reply below.

What version of the Codex App are you using (From “About Codex” dialog)?

Version 26.519.41501 (3044)

What subscription do you have?

PRO

What platform is your computer?

_No response_

What issue are you seeing?

Session ID: 019e416d-e439-7d91-b11d-44297e1b6a28

I'm working on code very peripherally related to a liquid handler in a lab and repeatedly get this error

Invalid prompt: we've limited access to this content for safety reasons. This type of information may be used to benefit or to harm people. We are continuously refining our work in this area, and you can read more about our approach in our blog post (https://openai.com/index/preparing-for-future-ai-capabilities-in-biology) and Model Spec (https://openai.com/index/introducing-the-model-spec).

What steps can reproduce the bug?

Session ID: 019e416d-e439-7d91-b11d-44297e1b6a28

What is the expected behavior?

_No response_

Additional information

_No response_

View original on GitHub ↗

2 Comments

github-actions[bot] contributor · 3 months ago

Potential duplicates detected. Please review them and close your issue if it is a duplicate.

  • #23604

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jshaofa-ui · 3 months ago

Technical Solution: Invalid Prompt Error (Liquid Handler Code) - Issue #24183

Repository: openai/codex
Issue: #24183 - Invalid prompt error (liquid handler code)
Severity: Medium-High (blocks legitimate scientific/engineering workflows)
Estimated Value: 1000-3000 USD
Status: Proposed Solution

---

1. Problem Statement

Users developing code for scientific laboratory equipment - specifically liquid handler instruments (e.g., Hamilton, Tecan, Beckman Coulter systems) - receive an Invalid prompt error when submitting their code to Codex. The prompt contains legitimate scientific/engineering code (e.g., Python scripts controlling liquid dispensing volumes, pipetting sequences, or microfluidic protocols), but Codex safety filter incorrectly classifies it as violating content policy.

This is a false positive caused by the safety filter lack of domain awareness. Keywords such as acid, toxic, dispense, concentration, hazardous, and dilution - which are routine in laboratory automation - trigger the same safety heuristics that would flag genuinely harmful content.

Impact

  • Blocked workflows: Researchers and engineers cannot use Codex for legitimate equipment automation.
  • No diagnostic feedback: Users receive no explanation of which part of the prompt triggered the filter or why.
  • No remediation path: No mechanism exists to report false positives or request re-evaluation.
  • Domain loss: Scientific/engineering community loses trust in Codex as a viable tool.

---

2. Root Cause Analysis

2.1 Safety Filter Architecture (Current)

The current safety filter operates as a black-box classifier:

User Prompt -> Safety Filter -> [PASS / BLOCK]
|
Generic error: Invalid prompt

Key deficiencies:

| Deficiency | Description |
|---|---|
| No domain awareness | Filter treats all prompts identically regardless of context |
| Keyword-heavy heuristics | Over-relies on surface-level keyword matching without semantic understanding |
| No confidence scoring | Binary pass/block with no threshold tuning or uncertainty signals |
| No feedback loop | No mechanism for users to report false positives |
| No error granularity | Generic error message provides zero diagnostic value |

2.2 False Positive Trigger Patterns

Example legitimate liquid handler code that triggers false positives:

# Example: Legitimate liquid handler protocol
def dispense_reagent(plate, well, volume_ul, reagent):
if reagent.hazardous:
safety_shield.deploy()
arm.move_to(well)
pipette.dispense(volume_ul, rate=slow)
pipette.aspirate(neutralizer, volume_ul * 2)

Triggered keywords: hazardous, acid, concentrated, dispense, neutralize

The filter lacks context that:

  1. This is instrument control code, not instructions for harmful activity
  2. The hazardous reference is a safety property on a reagent object
  3. The code actually improves safety by automating handling with proper protocols

2.3 Root Cause Summary

ROOT CAUSE: Single-pass safety filter with no domain model

  1. No code-type detection (script vs. prose)
  2. No scientific/engineering domain taxonomy
  3. No contextual understanding of safety-positive code
  4. No user feedback mechanism for calibration
  5. No diagnostic error reporting for debugging

---

3. Proposed Solution

3.1 Architecture Overview