Invalid prompt error (while I'm working on code that runs a liquid handler)
Open 💬 2 comments Opened May 23, 2026 by teedr
💡 Likely answer: A maintainer (github-actions[bot], contributor)
responded on this thread — see the highlighted reply below.
What version of the Codex App are you using (From “About Codex” dialog)?
Version 26.519.41501 (3044)
What subscription do you have?
PRO
What platform is your computer?
_No response_
What issue are you seeing?
Session ID: 019e416d-e439-7d91-b11d-44297e1b6a28
I'm working on code very peripherally related to a liquid handler in a lab and repeatedly get this error
Invalid prompt: we've limited access to this content for safety reasons. This type of information may be used to benefit or to harm people. We are continuously refining our work in this area, and you can read more about our approach in our blog post (https://openai.com/index/preparing-for-future-ai-capabilities-in-biology) and Model Spec (https://openai.com/index/introducing-the-model-spec).
What steps can reproduce the bug?
Session ID: 019e416d-e439-7d91-b11d-44297e1b6a28
What is the expected behavior?
_No response_
Additional information
_No response_
2 Comments
Potential duplicates detected. Please review them and close your issue if it is a duplicate.
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Technical Solution: Invalid Prompt Error (Liquid Handler Code) - Issue #24183
Repository: openai/codex
Issue: #24183 - Invalid prompt error (liquid handler code)
Severity: Medium-High (blocks legitimate scientific/engineering workflows)
Estimated Value: 1000-3000 USD
Status: Proposed Solution
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1. Problem Statement
Users developing code for scientific laboratory equipment - specifically liquid handler instruments (e.g., Hamilton, Tecan, Beckman Coulter systems) - receive an Invalid prompt error when submitting their code to Codex. The prompt contains legitimate scientific/engineering code (e.g., Python scripts controlling liquid dispensing volumes, pipetting sequences, or microfluidic protocols), but Codex safety filter incorrectly classifies it as violating content policy.
This is a false positive caused by the safety filter lack of domain awareness. Keywords such as acid, toxic, dispense, concentration, hazardous, and dilution - which are routine in laboratory automation - trigger the same safety heuristics that would flag genuinely harmful content.
Impact
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2. Root Cause Analysis
2.1 Safety Filter Architecture (Current)
The current safety filter operates as a black-box classifier:
User Prompt -> Safety Filter -> [PASS / BLOCK]
|
Generic error: Invalid prompt
Key deficiencies:
| Deficiency | Description |
|---|---|
| No domain awareness | Filter treats all prompts identically regardless of context |
| Keyword-heavy heuristics | Over-relies on surface-level keyword matching without semantic understanding |
| No confidence scoring | Binary pass/block with no threshold tuning or uncertainty signals |
| No feedback loop | No mechanism for users to report false positives |
| No error granularity | Generic error message provides zero diagnostic value |
2.2 False Positive Trigger Patterns
Example legitimate liquid handler code that triggers false positives:
# Example: Legitimate liquid handler protocol
def dispense_reagent(plate, well, volume_ul, reagent):
if reagent.hazardous:
safety_shield.deploy()
arm.move_to(well)
pipette.dispense(volume_ul, rate=slow)
pipette.aspirate(neutralizer, volume_ul * 2)
Triggered keywords: hazardous, acid, concentrated, dispense, neutralize
The filter lacks context that:
2.3 Root Cause Summary
ROOT CAUSE: Single-pass safety filter with no domain model
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3. Proposed Solution
3.1 Architecture Overview